Fic and non-Fic AMPylases: protein AMPylation in metazoans
نویسندگان
چکیده
منابع مشابه
Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain.
The bacterial pathogen Vibrio parahemeolyticus manipulates host signaling pathways during infections by injecting type III effectors into the cytoplasm of the target cell. One of these effectors, VopS, blocks actin assembly by AMPylation of a conserved threonine residue in the switch 1 region of Rho GTPases. The modified GTPases are no longer able to interact with downstream effectors due to st...
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BACKGROUND The Vibrio parahaemolyticus type III secreted effector VopS contains a fic domain that covalently modifies Rho GTPase threonine with AMP to inhibit downstream signaling events in host cells. The VopS fic domain includes a conserved sequence motif (HPFx[D/E]GN[G/K]R) that contributes to AMPylation. Fic domains are found in a variety of species, including bacteria, a few archaea, and m...
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ژورنال
عنوان ژورنال: Open Biology
سال: 2021
ISSN: 2046-2441
DOI: 10.1098/rsob.210009